I've watched This Week in Startups hosted by Jason Calacanis since episode one. It's an invaluable resource about startups and entrepreneurship. It's also great as Jason is always able to get great anecdotes out of his guests. This episode was no different.
Guest Jerry Colonna was truly amazing and probably the most inspirational episode I've watched. It tops my list of other great guests including David Heinemeier Hansson (which I read the news on), Chris Sacca and Gary Vaynerchuk.